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Federal government websites often end in. The site is secure. Preview improvements coming to the PMC website in October Learn More or Try it out now. Humans have had a long and complex relationship with salt. While highly valued in many societies, dietary salt has long been associated with high blood pressure 1 - 3 and, more recently, with other diseases.
Furthermore, individuals with high blood pressure are at increased risk for multiple diseases i. Our understanding of the effect of salt on health has grown even more complex recently. Researchers have reported a new connection between salt and autoimmunity: a high-salt diet was shown to accelerate autoimmune activity in a mouse model of multiple sclerosis. The WG brought together experts from diverse backgrounds including hypertension, epidemiology, preeclampsia, cardiovascular disease, kidney disease, and autoimmune diseases.
The WG reviewed existing and emerging scientific evidence that connects salt to human diseases, with a focus on hypertension and immune diseases Fig. The main areas of discussion addressed the bases of relationships between i dietary salt and hypertension, ii salt, autoimmunity, and cardiovascular diseases, and iii hypertension and immunity in various organs and systems brain, kidney, skin, and vasculature.
The WG also discussed the potential role of intrinsic factors e. Since the WG members came from diverse backgrounds, the meeting provided an excellent opportunity for cross-disciplinary thinking and discussions and highlighted the potential for future collaborations and research topics. In this report, we provide a brief summary of the WG discussion and recent progress in this area. An NHLBI working group was held to discuss current scientific evidence and knowledge and to identify new research topics that could be tested experimentally in animal models and early clinical studies to examine the effect of multiple interactions and the direction cause-effect of these relationships.
