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Federal government websites often end in. The site is secure. Preview improvements coming to the PMC website in October Learn More or Try it out now. The ADNI demographic, genetic, neuroimaging and neuropsychology data that were used in our analyses are available for eligible users for access and download at the ADNI data repository adni.

The NACC demographic, genetic, neuropathology and neuropsychology data that were used can be accessed freely by eligible researchers through the NACC website alz. In this study, we aimed to assess whether women are able to withstand more tau before exhibiting verbal memory impairment. Women demonstrated higher reserve i. Within each subgroup, we compared Logical Memory scores between men and women.

Taken together, our results point to a sex-related verbal memory reserve. In this study, we demonstrated in two independent cohorts that, for a given level of tau pathology, women perform better than men on verbal memory tests. Our findings suggest that women exhibit cognitive reserve, such that they are able to tolerate more tau before showing verbal memory impairment. Cognitive reserve has been attributed to factors such as education Stern et al.

Sex may also play a role in reserve, with women demonstrating higher reserve in verbal memory Beinhoff et al. This is supported by a pair of recent imaging studies, which reported that women, while expressing similar levels of neurodegeneration Sundermann et al. Recent studies have revealed sex differences in tau pathology.