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Federal government websites often end in. The site is secure. Preview improvements coming to the PMC website in October Learn More or Try it out now. Data curation: JMB. Formal analysis: JMB.
Funding acquisition: GMGS. Resources: GMGS. Software: JMB. Part of Video 1 slowed down to one-tenth speed, with tracking added. The DeepLabCut-tracked position of the nose is indicated by blue circles and each hand by red circles.
The derived hand-hand and hand-nose distances are indicated by red and blue lines, respectively. Example oromanual event with optogenetic silencing, slowed to one-tenth speed. Current behavioral mode, laser state, and regrips are noted.
Example spontaneous transport-to-mouth movement, slowed to one-tenth speed, followed by a transport-to-mouth movement evoked by corticospinal stimulation. Movement and laser onsets are noted. Food-handling offers unique yet largely unexplored opportunities to investigate how cortical activity relates to forelimb movements in a natural, ethologically essential, and kinematically rich form of manual dexterity. To determine these relationships, we recorded high speed fps video and multi-channel electrophysiological cortical spiking activity while mice handled food.